Discovery in medicine.
نویسندگان
چکیده
منابع مشابه
Discovery Medicine
Discovery Medicine, volume 19, Number 106, Pages 349-358, May 2015 Abstract: Differences between animals and humans in liver pathways now necessitate the use of in vitro models of the human liver for several applications such as drug screening. However, isolated primary human hepatocytes (PHHs) are a limited resource for building such models given shortages of donor organs. In contrast, human e...
متن کاملDiscovery Medicine
Discovery Medicine, Volume 12, Number 64, Pages n-n, September 2011 Abstract: Multiple sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous system (CNS) through demyelination and neurodegeneration. Until recently, major therapeutic treatments have relied on agents requiring injection delivery. In September 2010, fingolimod/FTY720 (Gilenya, Novartis) was approved by the ...
متن کاملDiscovery Medicine
Discovery Medicine, Volume 12, Number 67, Pages 461-470, december 2011 Abstract: Control of Gram-negative bacterial infections of plants and animals remains a major challenge because conventional approaches are often not sufficient to eradicate these infections. One major reason for their persistence seems to be the capability of the bacteria to grow within biofilms that protect them from adver...
متن کاملDiscovery Medicine
Discovery Medicine, Volume 14, Number 77, pages 229-236, october 2012 Abstract: Costimulation and coinhibition generated by the B7 family and their receptor CD28 family have key roles in regulating T lymphocyte activation and tolerance. These pathways are very attractive therapeutic targets for human cancers including breast cancer. Gene polymorphisms of B7x (B7H4/B7S1), PD-1 (CD279), and CTLA-...
متن کاملDiscovery Medicine
Discovery Medicine, Volume 18, Number 100, Pages n-n, November 2014 Abstract: Beyond acute clinical conditions, the role of enteroviruses (EVs) in chronic human diseases has been described. Although they are considered as highly cytolytic viruses, EVs can persist in various tissues. The persistence is believed to play a major role in the pathogenesis of EV related chronic diseases such as type ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1991
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.303.6817.1569